Optical Imaging and Spectroscopy Techniques
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A compact side-viewing endoscopic platform that integrates a chip-on-tip micro-camera with time-domain diffuse optical spectroscopy (TD-DOS), enabling surface imaging and depth-resolved tissue characterization within a 4.0~mm diameter catheter is presented.
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Abstract Several techniques have been developed for real-time tissue characterization; however, none are likely to meet the sensitivity and specificity requirements for medical diagnosis on their own. Multimodal sensing is thereby an important path towards improving the accuracy of real-time tissue characterization. In endoscopy, it is often nontrivial to accomplish such sensing in the form factor required for some applications considered. We present a compact side-viewing endoscopic platform that integrates a chip-on-tip micro-camera with time-domain diffuse optical spectroscopy (TD-DOS), enabling surface imaging and depth-resolved tissue characterization within a 4.0~mm diameter catheter. System performance was validated using standard MEDPHOT phantoms, while a custom hybrid multilayer phantom was employed to assess accuracy, depth sensitivity, and imaging resolution. Representative \textit{in vivo} measurements were made at the forearm location to demonstrate the depth sensitivity of the probe. The results illustrate that the platform reliably retrieves tissue optical properties and produces clear structural images.
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@article{Yavari2026Multimodal,
title = {Multimodal endoscopy platform combining superficial tissue chip-on-tip micro-camera imaging and depth-resolved time-domain diffuse optical spectroscopy},
author = {Hasti Yavari and Suraj Kumar Kumar Kothuri and Pranav Lanka and Stefan Andersson‐Engels and Sanathana Konugolu Venkata Sekar},
journal = {Journal of Physics Photonics},
year = {2026},
doi = {10.1088/2515-7647/ae889e},
url = {https://doi.org/10.1088/2515-7647/ae889e}
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