Muscle and Compartmental Disorders Peer reviewed

Diabetic myonecrosis

T Burbach, Clay W. Walker

JAAPA | Jun 23, 2026

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A patient with a history of poorly controlled type 2 diabetes who experienced persistent left thigh pain and swelling that was ultimately diagnosed as diabetic myonecrosis is described, highlighting the importance of recognizing these symptoms.

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ABSTRACT: Diabetic myonecrosis, also referred to as diabetic muscle infarction, is an uncommon complication of uncontrolled diabetes mellitus. This diagnosis typically occurs in patients who have chronic, poorly controlled diabetes; patients often experience additional diabetic complications. The presentation of diabetic myonecrosis involves an acute onset of swelling and pain in the affected area, typically involving a unilateral lower extremity. Diagnosis is often delayed due to the rarity of the condition, along with the need for advanced diagnostic testing such as MRI or muscle biopsy for confirmation. This case report describes a patient with a history of poorly controlled type 2 diabetes who experienced persistent left thigh pain and swelling that was ultimately diagnosed as diabetic myonecrosis, highlighting the importance of recognizing these symptoms.

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T Burbach

first | New York Times

Clay W. Walker

last

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@article{Burbach2026Diabetic,
  title = {Diabetic myonecrosis},
  author = {T Burbach and Clay W. Walker},
  journal = {JAAPA},
  year = {2026},
  doi = {10.1097/01.jaa.0000000000000367},
  url = {https://doi.org/10.1097/01.jaa.0000000000000367}
}

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