GDF15 and Related Biomarkers Open access Peer reviewed

GDF15 biomarker performance in older patients with advanced non-small cell lung cancer

Nicholas McNamee, Rachael A. McCloy, Bernadette (Bea) Brown, Michael Krasovitsky and 4 more

Journal of Geriatric Oncology | Jun 9, 2026

Abstract

Abstract

Lung cancer is a lethal disease responsible for the highest number of annual cancer deaths by cancer type, estimated to be 127,070 in the United States in 2023 [1]. It has a high impact on older patients with a median age of diagnosis at 71, however, this age group has not been well represented in many pivotal clinical trials. An analysis of lung cancer trials from 1990 to 2012 showed just 25.3% of patients were aged ≥70 [2]. Whilst there is increasing evidence that older people benefit from anti-cancer therapies [3], there are precious few tools to identify those most likely to tolerate and benefit from treatment.

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Authors

Researchers on this paper

Nicholas McNamee

first | The Kinghorn Cancer Centre

Rachael A. McCloy

middle | Garvan Institute of Medical Research | ORCID 0000-0001-7791-4044

Bernadette (Bea) Brown

middle | The University of Sydney

Michael Krasovitsky

middle | Garvan Institute of Medical Research

Anthony Joshua

middle | Garvan Institute of Medical Research

Michael Boyer

middle | Chris O’Brien Lifehouse | ORCID 0000-0002-0452-2987

John Simes

middle | The University of Sydney

Venessa Chin

last | Garvan Institute of Medical Research | ORCID 0000-0002-4630-4451

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Citation

BibTeX

@article{McNamee2026GDF15,
  title = {GDF15 biomarker performance in older patients with advanced non-small cell lung cancer},
  author = {Nicholas McNamee and Rachael A. McCloy and Bernadette (Bea) Brown and Michael Krasovitsky and Anthony Joshua and Michael Boyer and John Simes and Venessa Chin},
  journal = {Journal of Geriatric Oncology},
  year = {2026},
  doi = {10.1016/j.jgo.2026.103028},
  url = {https://doi.org/10.1016/j.jgo.2026.103028}
}

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