Multiple Sclerosis Research Studies
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B-cell depletion is associated with reduced CLTE, a promising biomarker of progressive MS biology, a retrospective, observational study using linked clinical data from MSBase and the MSBase Imaging Repository.
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Background: Chronic lesion tissue expansion (CLTE) reflects slow, concentric growth of established multiple sclerosis (MS) lesions and is linked to central brain atrophy and disability progression. Whether existing MS disease-modifying therapies (DMTs) differentially influence this aspect of progressive MS biology remains unclear. Objectives: To compare the effect of current DMTs on CLTE in a multicentre, real-world MS cohort. Methods: We conducted a retrospective, observational study using linked clinical data from MSBase and the MSBase Imaging Repository. Data from patients aged ⩾18 years with ⩾3 longitudinal MRI scans, and 7 therapies with ⩾100 stable treatment epochs were included. Therapy effects on CLTE, new T2 lesions, and brain atrophy were assessed using epoch-based covariate-adjusted generalised estimating equation models, with fingolimod as a comparator. Result: The cohort included 564 patients contributing 1648 stable treatment epochs. After adjustment for demographic, clinical, and imaging covariates, B-cell depleting therapy was the only DMT associated with significantly lower CLTE (β = −4.03, p = 0.017) relative to fingolimod. CLTE was independently associated with age, baseline lesion volume, and centre effects. Conclusions: B-cell depletion is associated with reduced CLTE, a promising biomarker of progressive MS biology.
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@article{Guilfoyle2026Impact,
title = {Impact of multiple sclerosis disease-modifying therapies on chronic lesion tissue expansion},
author = {Daniel Guilfoyle and Kayla Ward and Samuel Klistorner and Nathaniel Lizak and Heidi Beadnall and Robert Zivadinov and Bianca Weinstock‐Guttman and Izanne Roos and Helmut Butzkueven and Anneke van der Walt and K Buzzard and Olga Skibina and M.G. Dwyer and Yael Barnett and E O Lui and Meng Law and Andy Shieh and Alexander Klistorner and Chenyu Wang and Tomáš Kalinčík and Michael Barnett},
journal = {Multiple Sclerosis Journal},
year = {2026},
doi = {10.1177/13524585261459228},
url = {https://doi.org/10.1177/13524585261459228}
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