Health disparities and outcomes
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Assessment of the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study reveals that low education emerges as the leading factor for both all-cause and cancer mortality.
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Nationwide estimates of the impact of common modifiable risk factors on mortality remain crucial. We aim to assess the influence of social determinants, lifestyle, and metabolic factors on mortality in 174,004 adults aged ≥40 years from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. We reveal that 17 modifiable factors are independently associated with mortality, accounting for 64.8% of all-cause mortality, 77.4% of cardiovascular mortality, and 44.8% of cancer mortality. Low education emerges as the leading factor for both all-cause and cancer mortality, while hypertension is predominant for cardiovascular mortality. Moreover, low gross domestic product per capita and high ambient particulate matter with a diameter of 2.5) air pollution account for 7.8% and 4.3% for all-cause mortality, respectively, using a different method. Gender-specific analyses reveal distinct patterns, with women's mortality primarily associated with social determinants and men exhibiting stronger associations with lifestyle factors. Targeted health interventions are essential to mitigate mortality risks effectively in China.
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@article{Li2024Association,
title = {Association of social determinants, lifestyle, and metabolic factors with mortality in Chinese adults: A nationwide 10-year prospective cohort study},
author = {Yan Li and Jieli Lu and Mian Li and Jiang He and Yu Xu and Ruizhi Zheng and Jie Zheng and Guijun Qin and Yingfen Qin and Yu‐Hong Chen and Xulei Tang and Zhen Ye and Min Xu and Tiange Wang and Lixin Shi and Qing Su and Xuefeng Yu and Zhiyun Zhao and Qin Wan and Gang Chen and Zhengnan Gao and Guixia Wang and Feixia Shen and Xuejiang Gu and Zuojie Luo and Lixia Chen and Xinguo Hou and Yanan Huo and Qiang Li and Hong Qiao and Yinfei Zhang and Tianshu Zeng and Chunyan Hu and Qiuyu Cao and Xiaojing Jia and Chao Liu and Youmin Wang and Shengli Wu and Tao Yang and Huacong Deng and Hongyan Qi and Xueyan Wu and Di Zhang and Meng Dai and Donghui Li and Shenghan Lai and Lulu Chen and Jiajun Zhao and Yiming Mu and Weiguo Hu and Guang Ning and Ruying Hu and Yufang Bi and Weiqing Wang},
journal = {Cell Reports Medicine},
year = {2024},
doi = {10.1016/j.xcrm.2024.101656},
url = {https://doi.org/10.1016/j.xcrm.2024.101656}
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