Mechanical Circulatory Support Devices
Open access
Peer reviewed
Scollr summary
What this paper is about
In patients with cardiogenic shock supported by PVAD, the early trajectory of hRVD provides prognostic information and may guide timely escalation of right-heart-targeted therapies.
Full abstract
Read the full abstract
BACKGROUND: Right ventricular dysfunction (RVD) is common in cardiogenic shock and associated with poor outcomes. However, early RVD trajectories after initiation of percutaneous ventricular assist device (PVAD) support and their prognostic implications remain unclear. OBJECTIVES: The objectives of the study was to characterize the trajectory of hemodynamic RVD (hRVD) during the first 24 hours after PVAD initiation and evaluate its association with outcomes. METHODS: This study included patients with cardiogenic shock treated with PVAD from the UNLOADERS-PVAD registry. RVD was hemodynamically defined by an elevated right atrial pressure ≥15 mm Hg and/or a low pulmonary artery pulsatility index <0.9. Hemodynamic assessments were performed pre-PVAD, early post-PVAD, and 24 h post-PVAD. The primary endpoint was a composite of all-cause mortality or reintroduction of mechanical circulatory support after PVAD discontinuation within 30 days. RESULTS: Among 463 patients with available data, hRVD was present in 52% (63/121) pre-PVAD, decreased to 48% (211/443) early post-PVAD, and further to 39% (169/436) at 24 h post-PVAD. hRVD trajectories were heterogeneous, with improvement predominating over deterioration. The median follow-up from PVAD implantation was 27 (12-30) days. Persistent or worsening hRVD at 24 h post-PVAD was associated with a higher risk of the primary endpoint. Elevated right atrial pressure was associated with adverse outcomes only at 24 h post-PVAD, whereas low pulmonary artery pulsatility index was consistently associated with adverse outcomes across all time points. CONCLUSIONS: In patients with cardiogenic shock supported by PVAD, the early trajectory of hRVD provides prognostic information. Persistent or worsening hRVD at 24 hours identifies high-risk patients and may guide timely escalation of right-heart-targeted therapies. (UNLOADERS-PVAD [Unloading and Heart Recovery with Advanced Mechanical Circulatory Support: Optimal Management of Percutaneous Ventricular Assist Device] UMIN000052966).
Direct answer
What can I do from this paper page?
Use this page to scan "Early-Phase Trajectory of Right Ventricular Hemodynamics during Microaxial Flow Pump Support for Cardiogenic Shock" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Mechanical Circulatory Support Devices research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Ikeda2026Early,
title = {Early-Phase Trajectory of Right Ventricular Hemodynamics during Microaxial Flow Pump Support for Cardiogenic Shock},
author = {Yuki Ikeda and Keita Saku and Jun Nakata and Takashi Unoki and S. Nakahara and Toshiyuki Iwaya and Saeko Iikura and Yu Takigami and Takeshi Yamamoto and Tomohiro Sakamoto and Junya Ako},
journal = {JACC Advances},
year = {2026},
doi = {10.1016/j.jacadv.2026.103165},
url = {https://doi.org/10.1016/j.jacadv.2026.103165}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Mechanical Circulatory Support Devices research papers?
Follow Mechanical Circulatory Support Devices research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Early-Phase Trajectory of Right Ventricular Hemodynamics during Microaxial Flow Pump Support for Cardiogenic Shock. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app