Thermal Regulation in Medicine
Abstract
Abstract
Background: Post-spinal shivering (PSS) is a frequent complication of spinal anaesthesia during caesarean section, causing patient discomfort and potential physiological disturbances. Both nefopam and ondansetron possess anti-shivering properties; however, comparative evidence in obstetric patients is limited. The objective of this study is to compare the efficacy and safety of intravenous nefopam and ondansetron in preventing post-spinal shivering in women undergoing elective caesarean section under spinal anaesthesia. Methodology: This randomised controlled study included 96 ASA II parturients scheduled for elective caesarean section under spinal anaesthesia. Participants were randomly allocated into three groups (n = 32 each). Group N received intravenous nefopam (0.15 mg/kg), Group O received intravenous ondansetron (0.1 mg/kg), and Group P received 10 mL of normal saline as a placebo. The medications were administered 15 minutes before spinal anaesthesia. Patients were monitored for the incidence and severity of shivering using the Crossley and Mahajan scale. Side effects and the need for rescue medication (intravenous pethidine 0.5 mg/kg) were also recorded. Statistical significance was set at p < 0.05. Results: The incidence of PSS was significantly lower in Group N (18.8%) and Group O (18.8%) compared with Group P (59.4%) (p < 0.001). Severe shivering (grades 3-4) occurred only in the placebo group (40.5%). Consequently, the need for rescue pethidine was significantly higher in Group P (37.5%), while none of the patients in Groups N or O required it (p < 0.001). Postoperative nausea was less frequent in Group O (3.1%) and Group N (12.5%) compared with Group P (25%) (p < 0.05). Mild injection-site pain occurred only in Group N (9.4%). Conclusion: Intravenous nefopam and ondansetron are similarly effective in preventing post-spinal shivering and reducing rescue analgesia requirements during caesarean section under spinal anaesthesia. Ondansetron showed better antiemetic effect, while nefopam was associated with mild injection-site discomfort.
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@article{Malau2026Prophylactic,
title = {Prophylactic Efficacy of Intravenous Nefopam Versus Ondansetron in Preventing Post-Spinal Shivering in Parturients Undergoing Elective Caesarean Section: A Double-Blind Randomised Controlled Trial.},
author = {Kefas Thomas Malau and Yohanna Musa Usman and Precious Barisi Kpalap and Rimamkanati Christopher Shaki and Husseina Amina Aliyu and Aliyu Musa Abdullahi and Jude Adikwu Agbo and Uga Donald Orshio and Mangai Audu Ngeh and Samuel I. Nuhu and Henry Y. Embu and Erdoo S. Isamade},
journal = {PubMed},
year = {2026},
url = {https://pubmed.ncbi.nlm.nih.gov/42544185}
}FAQ
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