Antioxidant Activity and Oxidative Stress
Open access
Peer reviewed
Scollr summary
What this paper is about
It is indicated that lycopene Z -isomers exhibit broader antiproliferative activity than the all- E -isomer in this in vitro screening platform and warrant further mechanistic and in vivo studies.
Full abstract
Read the full abstract
Abstract Lycopene occurs as multiple geometrical isomers, whereas most studies on its cancer-related effects have focused on the all- E -isomer or on preparations with an undefined isomer composition. In this study, the antiproliferative activities of all- E -isomer-rich lycopene preparation ( E -LYC) and Z -isomer-rich lycopene preparation ( Z -LYC) were compared using a panel of 102 human cancer cell lines under identical experimental conditions. Z -LYC showed a broader antiproliferative profile than E -LYC, with IC 50 values within the tested concentration range (3.16–31,600 nM) in 91 and 16 cell lines, respectively. Tissue sensitivity analysis indicated that lymphoid malignancies and leukemia were relatively sensitive to Z -LYC, with additional sensitivity observed in bone, soft tissue, ovarian, and testicular germ cell tumors. Phenotypic similarity analysis further showed broader correlations for Z -LYC than E -LYC with reference anticancer agents, suggesting a more distinct biological response profile at the cellular level. Preliminary molecular docking simulations also suggested that lycopene Z -isomers may interact more favorably than the all- E -isomer with selected cancer-related proteins. These findings indicate that lycopene Z -isomers exhibit broader antiproliferative activity than the all- E -isomer in this in vitro screening platform and warrant further mechanistic and in vivo studies.
Direct answer
What can I do from this paper page?
Use this page to scan "Screening of the antiproliferative activity of lycopene isomers in a panel of human cancer cell lines: Lycopene Z-isomers exhibit greater activity than the all-E-isomer" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Antioxidant Activity and Oxidative Stress research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Honda2026Screening,
title = {Screening of the antiproliferative activity of lycopene isomers in a panel of human cancer cell lines: Lycopene Z-isomers exhibit greater activity than the all-E-isomer},
author = {Masaki Honda and Kako Matsumoto and Asih Gayatri and Mitsuya Ito and Kazumi Sawada and Kento Nakamura},
journal = {Scientific Reports},
year = {2026},
doi = {10.1038/s41598-026-65208-x},
url = {https://doi.org/10.1038/s41598-026-65208-x}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Antioxidant Activity and Oxidative Stress research papers?
Follow Antioxidant Activity and Oxidative Stress research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Screening of the antiproliferative activity of lycopene isomers in a panel of human cancer cell lines: Lycopene Z-isomers exhibit greater activity than the all-E-isomer. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app