Adipokines, Inflammation, and Metabolic Diseases
Open access
Peer reviewed
Scollr summary
What this paper is about
This work systematically profile co-stimulatory molecules in adipocytes and adipose tissue macrophages and identifies OX40 ligand (OX40L) as the most robustly upregulated in obesity.
Full abstract
Read the full abstract
T cells contribute critically to obesity-induced adipose inflammation and insulin resistance, yet the co-stimulatory signals that govern their activation in adipose tissue remain unclear. Here, we systematically profile co-stimulatory molecules in adipocytes and adipose tissue macrophages and identify OX40 ligand (OX40L) as the most robustly upregulated in obesity. OX40L is also elevated in adipocytes from obese humans. Although macrophage-specific OX40L deletion has no metabolic impact, global OX40 deficiency or adipocyte-specific OX40L deletion reduces Th1 cell accumulation in visceral adipose tissue, attenuates inflammation and improves insulin sensitivity without affecting adiposity. These benefits are reversed by Th1 cell transfer. Therapeutic blockade of OX40L with a neutralizing antibody mimics the protective effects of genetic deletion. Our findings identify adipocyte-derived OX40L as a critical mediator of obesity-associated immune dysfunction and establish it as a targetable checkpoint for tissue-specific immunotherapy in metabolic disease.
Direct answer
What can I do from this paper page?
Use this page to scan "Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Adipokines, Inflammation, and Metabolic Diseases research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Song2026Adipocyte,
title = {Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity},
author = {Jianfeng Song and Qin Zeng and Yayi Jiao and Xiaoxiao Sun and Limin Xie and J L Qiu and Yujin Ding and Wanyu Hu and Fang Wang and Biling Huang and Wuqian Mai and Ying Mei and Dandan Wang and Lan Xie and Xiang Xiao and Liu W and Willa A. Hsueh and X Li and Tuo Deng},
journal = {Experimental & Molecular Medicine},
year = {2026},
doi = {10.1038/s12276-026-01770-8},
url = {https://doi.org/10.1038/s12276-026-01770-8}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Adipokines, Inflammation, and Metabolic Diseases research papers?
Follow Adipokines, Inflammation, and Metabolic Diseases research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Adipocyte OX40L promotes adipose T cell activation and insulin resistance in obesity. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app