Pharmacological Effects and Toxicity Studies
Open access
Peer reviewed
Scollr summary
What this paper is about
The case of a young female patient with medically refractory epilepsy who elected to continue cenobamate throughout two of her pregnancies and lactation and had a significant reduction in the frequency of her seizures is presented.
Full abstract
Read the full abstract
Seizures remain the most frequent major neurologic complication during pregnancy, affecting 0.3% to 0.8% of all gestations. In clinical practice, the risk of seizures during pregnancy is weighed against the risks of antiseizure drug (ASD) exposure (e.g. teratogenicity, congenital malformations, developmental, and intrauterine growth). With the advent of novel ASDs, further research into the specific risks of these novel medications during pregnancy is warranted. Cenobamate, a novel ASD approved by the Food and Drug Administration (FDA) for focal onset epilepsy in adults is highly efficacious, however, all trials of this novel ASD to date excluded pregnant and lactating subjects. For this reason, we present the case of a young female patient with medically refractory epilepsy who elected to continue cenobamate throughout two of her pregnancies and lactation. Our patient had a significant reduction in the frequency of her seizures. There were no complications during either pregnancy, delivery, and postpartum period. While a single case experience does not establish the safety and efficacy of cenobamate during pregnancy/lactation, patients of childbearing age who are currently considering or already taking cenobamate may benefit from knowledge regarding our patient’s experience.
Direct answer
What can I do from this paper page?
Use this page to scan "Safety and Efficacy of Cenobamate in Pregnancy: A Case Report" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Pharmacological Effects and Toxicity Studies research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{Nowakowski2026Safety,
title = {Safety and Efficacy of Cenobamate in Pregnancy: A Case Report},
author = {Lauren Nowakowski and Ashir Mehra and Brian Blankenship and Bryce Hoeslcher and Komal Ashraf},
journal = {Missouri health.},
year = {2026},
doi = {10.32469/3hj84w85},
url = {https://doi.org/10.32469/3hj84w85}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Pharmacological Effects and Toxicity Studies research papers?
Follow Pharmacological Effects and Toxicity Studies research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Safety and Efficacy of Cenobamate in Pregnancy: A Case Report. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app