Micro and Nano Robotics
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In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models, offering a promising solution for precise targeted drug delivery.
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Systemic drug administration often causes off-target effects, limiting the efficacy of advanced therapies. Targeted drug delivery approaches increase local drug concentrations at the diseased site while minimizing systemic drug exposure. We present a magnetically guided microrobotic drug delivery platform capable of precise navigation under physiological conditions. This platform integrates a clinical electromagnetic navigation system, a custom-designed release catheter, and a dissolvable capsule for accurate therapeutic delivery. In vitro tests showed precise navigation in human vasculature models, and in vivo experiments confirmed tracking under fluoroscopy and successful navigation in large animal models. The microrobot balances magnetic material concentration, contrast agent loading, and therapeutic drug capacity, offering a promising solution for precise targeted drug delivery.
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@article{Landers2025Clinically,
title = {Clinically ready magnetic microrobots for targeted therapies},
author = {Fabian C. Landers and Lukas Hertle and Vitaly Pustovalov and Derick Sivakumaran and Çağatay M. Oral and Oliver Brinkmann and Kirstin Meiners and Pascal Theiler and Valentin Gantenbein and Andrea Veciana and Michael Mattmann and Silas Riss and Simone Gervasoni and Christophe Chautems and Hao Ye and Semih Sevim and Andreas D. Flouris and Josep Puigmartí‐Luis and Tiago Sotto Mayor and Pedro G. Alves and Tessa Lühmann and Xiangzhong Chen and Nicole Ochsenbein-Kölble and Ueli Moehrlen and Tilman Schubert and Zsolt Kulcsár and Philipp Gruber and Miriam Weisskopf and Quentin Boehler and Salvador Pané and Bradley J. Nelson},
journal = {Science},
year = {2025},
doi = {10.1126/science.adx1708},
url = {https://doi.org/10.1126/science.adx1708}
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