Tryptophan and brain disorders
Open access
Peer reviewed
Scollr summary
What this paper is about
The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect of the immune response and the therapeutic opportunities presented from the mimicry of these metabolites or by targeting the enzymes that make or metabolize them in order to leverage the body's own anti-inflammatory response.
Full abstract
Read the full abstract
The reprogramming of metabolic pathways and processes in immune cells has emerged as an important aspect of the immune response. Metabolic intermediates accumulate as a result of metabolic adaptations and mediate functions outside of metabolism in the regulation of immunity and inflammation. In macrophages, there has been a major focus on 3 metabolites linked to the Krebs cycle, itaconate, succinate, and fumarate, which have been shown to regulate multiple processes. Here, we discuss recent progress on these 3 metabolites with regard to their effect on macrophages in host defense and inflammatory diseases. We also consider the therapeutic opportunities presented from the mimicry of these metabolites or by targeting the enzymes that make or metabolize them in order to leverage the body's own anti-inflammatory response.
Direct answer
What can I do from this paper page?
Use this page to scan "Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Tryptophan and brain disorders research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{PlssonMcDermott2025Gang,
title = {Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation},
author = {Eva M. Pålsson‐McDermott and Luke O'neill},
journal = {Cell Metabolism},
year = {2025},
doi = {10.1016/j.cmet.2025.03.004},
url = {https://doi.org/10.1016/j.cmet.2025.03.004}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Tryptophan and brain disorders research papers?
Follow Tryptophan and brain disorders research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Gang of 3: How the Krebs cycle-linked metabolites itaconate, succinate, and fumarate regulate macrophages and inflammation. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app