Antibiotic Resistance in Bacteria
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A high and growing burden of carbapenem-resistant K. pneumoniae in Thailand is highlighted, marked by notable geographic variation and a predominance of blaNDM and ESBL genes.
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Klebsiella pneumoniae is one of the major pathogens associated with multidrug resistance. This study aims to estimate the prevalence and characterize the molecular epidemiology of carbapenem-resistant K. pneumoniae in Thailand. We conducted a comprehensive search of PubMed, Embase, Scopus, ScienceDirect, and a Thai Journals Online (ThaiJO) from inception to November 19, 2024. Subgroup, meta-regression, and heterogeneity analyses were conducted. Publication bias was assessed using funnel plots and Egger’s test. The pooled prevalence estimates reflect proportions reported in published hospital-based studies. A total of 32 studies were included in the systematic review, with 27 studies included in the meta-analysis. The pooled proportion of carbapenem-resistant K. pneumoniae isolates was 87% (95% CI: 81%, 91%), with increasing trends observed for imipenem and meropenem resistance between 2014 and 2024. Ertapenem resistance remained high across regions, peaking in 2020 (100%) and 2024 (86%), particularly in the North and Northeast. The most prevalent carbapenemase gene was blaNDM (50%). Among the ESBL-associated genes, the pooled prevalence estimate was highest for blaCTX-M (86%). Co-harboring of blaNDM and blaOXA-48-like was observed in 36% of the isolates. Co-harboring of ESBL genes was detected in 25% of isolates. Subgroup and meta-regression analyses confirmed significant heterogeneity across regions and years. This meta-analysis highlights a high and growing burden of carbapenem-resistant K. pneumoniae in Thailand, marked by notable geographic variation and a predominance of blaNDM and ESBL genes. While the findings are indicative of important trends, the observed heterogeneity suggests that the results should be interpreted with caution.
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@article{Leerach2026Carbapenemase,
title = {Carbapenemase- and ESBL-producing Carbapenem-resistant Klebsiella pneumoniae in Thailand: A Systematic Review and Meta-analysis},
author = {Nontaphat Leerach and Narak Pravitra and Sopicha Aungkawimongkol and Natthanun Tawornsatit and Nitima Tatiya-aphiradee and Thawatchai Kitti and Payton To Yau and Sutthirat Sitthisak and Wiriya Mahikul},
journal = {Journal of Pure and Applied Microbiology},
year = {2026},
doi = {10.22207/jpam.20.3.65},
url = {https://doi.org/10.22207/jpam.20.3.65}
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