Neuroblastoma Research and Treatments
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Abstract
Abstract
Objective This study aims to elucidate the clinicopathological characteristics, molecular profiles, and prognostic outcomes of congenital neuroblastoma in Chinese infants. Methods A retrospective single-center analysis was conducted on 15 pathologically confirmed congenital neuroblastoma cases in China from 2017 to 2025. Clinical, imaging, pathological features and FISH for MYCN amplification and KMT2A rearrangement were evaluated. Results The cohort included 15 patients with a male-to-female ratio of 8:7. Eight cases were detected prenatally and seven within 28 postnatal days. Most tumors (12/15) arose in the adrenal gland. Preoperative serum NSE elevation was more sensitive than VMA. All patients underwent complete resection; one received adjuvant chemotherapy and one relapsed. No MYCN amplification or KMT2A rearrangement was found. Conclusion In this single-center Chinese cohort, congenital neuroblastoma showed favorable biological behavior. Complete resection achieved good outcomes. Combination of NSE and imaging examinations is promising for postoperative prognostic evaluation and recurrence surveillance in these pediatric patients.
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@article{Zhu2026Clinical,
title = {Clinical and pathological characteristics of congenital neuroblastoma in 15 Chinese infants: a retrospective analysis from a single-center},
author = {Li’ou Zhu and Ying Wu and Wen Zhang and 冯琼 and Dengyan Chen and Lili Liu},
journal = {Frontiers in Medicine},
year = {2026},
doi = {10.3389/fmed.2026.1854318},
url = {https://doi.org/10.3389/fmed.2026.1854318}
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