Plant Toxicity and Pharmacological Properties
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Assessment of anti-inflammatory activity using the LPS-stimulated inflammation model in RAW264.7 cells identified compounds 13 and 18 as potent inhibitors of NO generation and possible biosynthetic pathways for new compounds were speculated.
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Phytochemical investigations of the leaves of Staphylea arguta (Turpiniae Folium) resulted in the isolation of one new dimeric isoechinulin-type indole alkaloid, (+)-uncarilin C (1), one new seco-ursane-type nor-triterpenoid, 3β-hydroxy-19-oxo-18,19-seco-12,17dien-28-norursane (7), together with twenty known compounds (2–6 and 8–22). Compounds 1–9, 11–17, and 20–22 were first isolated from the genus Staphylea. A comprehensive spectroscopic analysis using NMR, HRESIMS, and ECD calculation established the new structures. Possible biosynthetic pathways for new compounds were speculated. Assessment of anti-inflammatory activity using the LPS-stimulated inflammation model in RAW264.7 cells identified compounds 13 and 18 as potent inhibitors of NO generation.
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@article{Wu2026Phytochemicals,
title = {Phytochemicals from the leaves of Staphylea arguta (Turpiniae Folium) and their anti-inflammatory activity},
author = {Shumin Wu and Feifei Tang and Xiyu Xu and Xiaoxiang Fan and Danting Luo and Yunqing He and Ping Hai and Shengxiang Yang and Yuan Gao and Jian Yang},
journal = {Natural Product Research},
year = {2026},
doi = {10.1080/14786419.2026.2690630},
url = {https://doi.org/10.1080/14786419.2026.2690630}
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