Seaweed-derived Bioactive Compounds
Open access
Peer reviewed
Scollr summary
What this paper is about
Both fractions exhibited antioxidant, anti-collagenase and anti-elastase activities and also a good biocompatibility and capacity to modulate the cell cycle progression in human dermal fibroblast culture.
Full abstract
Read the full abstract
Sulfated polysaccharides (SPs) from green seaweed species have been scarcely studied for the development of novel pharmaceutical, cosmetic or nutraceutical products. The present study aimed to investigate the physico-chemical characteristics of the sulfated polysaccharidic fractions isolated from Cladophora vagabunda green seaweed and to evaluate their anti-aging properties in vitro. SPF1 and SPF2 fractions were separated from the purified polysaccharidic extract by size exclusion chromatography. The content of neutral carbohydrates, uronic acids and sulfate was assessed, while Fourier transform infrared spectroscopy (FT-IR) analysis confirmed the presence of a functional group characteristic for sulfated polysaccharides. Capillary zone electrophoresis indicated the monosaccharides profile and the presence of bioactive fucose and uronic acids. The two fractions differed in sulfate content (22.59% and 29.44%). SF2 showed stronger collagenase inhibition (95.69%), whereas SF1 exhibited greater elastase inhibition (84.2%) in comparison with EGCG. Both fractions exhibited antioxidant, anti-collagenase and anti-elastase activities and also a good biocompatibility and capacity to modulate the cell cycle progression in human dermal fibroblast culture. They showed anti-inflammatory potential by inhibition of interleukin-1 beta (IL-1β), tumor necrosis factor-α (TNF-α) and nitric oxide (NO) production in lipopolysaccharide (LPS)-inflamed THP-1-derived macrophages. Also, the level of matrix metalloproteinase-1 (MMP-1) and MMP-9 secretion was reduced after treatment with C. vagabunda fractions with MMP-1 reduced by ~95% in both fractions and MMP-9 reduced by ~79% in SF2 compared with the control. Both fractions stimulated the growth of probiotic cultures Lactobacillus acidophilus and L. rhamnosus. All these results demonstrated, for the first time, the anti-aging potential of sulfated polysaccharides isolated from C. vagabunda green seaweed.
Direct answer
What can I do from this paper page?
Use this page to scan "Skin Anti-Aging Potential of Sulfated Polysaccharides from Cladophora vagabunda Green Seaweed" quickly: start with the summary and abstract, then check the authors, source, topics, and related papers. From here, open Scollr to follow Seaweed-derived Bioactive Compounds research, save the paper, or map adjacent work.
Research areas
Follow related topics
Citation
BibTeX
@article{GasparPintiliescu2026Skin,
title = {Skin Anti-Aging Potential of Sulfated Polysaccharides from Cladophora vagabunda Green Seaweed},
author = {Alexandra Gaspar-Pintiliescu and Ana-Maria Seciu-Grama and Ana-Maria Prelipcean and Andreia Alecu and Florentina Gatea and Otilia Zarnescu and Ticuţa Negreanu–Pîrjol and Oana Craciunescu},
journal = {Polysaccharides},
year = {2026},
doi = {10.3390/polysaccharides7030087},
url = {https://doi.org/10.3390/polysaccharides7030087}
}FAQ
Using this paper in a discovery workflow
How do I find related work for this paper?
Use the related papers and topic links on this page as starting points. In Scollr, you can also open the paper and build a literature map around its references, citing papers, and related work.
How can I keep up with new Seaweed-derived Bioactive Compounds research papers?
Follow Seaweed-derived Bioactive Compounds research in Scollr. New papers from the topic flow into a personalized feed, and you can save useful studies to revisit later.
Can I cite this paper from this page?
This page includes a static BibTeX block for Skin Anti-Aging Potential of Sulfated Polysaccharides from Cladophora vagabunda Green Seaweed. Always verify the DOI, source, and publication details against the publisher record before submitting a manuscript.
Follow this research in Scollr
Follow the topics and authors behind this paper, save useful studies, and build a literature map when you are ready to go deeper.
Get the app